Zhixun Dou

Metformin inhibits nuclear egress of chromatin fragments in senescence and aging

This study shows metformin inhibits chromatin fragment egress from the nucleus, reducing cGAS-STING activation and chronic inflammation in aging.

RamanOmics Decodes Spatial Vibrational-Molecular Architecture and Rewiring in Aging and Repair

RamanOmics integrates snRNA-seq, spatial transcriptomics, and Raman imaging to map spatial biochemical and molecular changes in aging and repair, identifying senescent cell signatures and their functional roles.

Limiting the impact of protein leakage in single-cell proteomics

The paper identifies a signature for protein leakage in single-cell proteomics and develops a classifier to detect damaged cells across species and cell types.

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons

This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.

Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.