Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells
Yaroslav E. Abramenko, Alvina I. Khamidullina, Tamara A Kiryukhina, Anna V. Tvorogova, Nataliya G Pavlenko, Alexandra V. Bruter, Victor Vyacheslavovich Tatarskiy
This study shows that the Eg5 inhibitor SB743921 induces p53-dependent cell cycle arrest, senescence, and death in tumor cells, particularly in TP53-mutated cells, with potential for combinational therapy with senolytic drugs.
bioRxiv · Jan 23, 2025 · PreprintCancer Biology