In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model
Sukhvir K. Wright, Richard Ewald Rosch, Max A Wilson, Manoj A. Upadhya, Divya Dhangar, Charlie Clarke-Bland, Tamara T. Wahid, Sumanta Barman, Norbert Goebels, Jakob Kreye, Harald Prüß, Leslie W. Jacobson, Danielle S. Bassett, Angela Carmen Vincent, Stuart Greenhill, Gavin L. Woodhall
This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.
bioRxiv · Dec 22, 2020 · PreprintNeuroscience