Jakob Kreye

Intrathecal antibodies cross-react with EBV BRRF2 and human antigens in multiple sclerosis

The paper identifies an intrathecal antibody response to EBV BRRF2 and human antigens in MS, showing cross-reactivity and association with increased IgG synthesis.

Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

The paper examines four new anti-Caspr2 antibodies, showing they target different epitopes and induce varying ASD-like phenotypes in male mice offspring.

Maternofetal transfer of human NMDAR-antibodies leads to cortical network defect in adolescence

This study shows that maternal-fetal transfer of NMDAR-antibodies causes lasting impairments in adolescent brain network function and connectivity.

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

Insights into standards of care: dexamethasone and antibodies against COVID-19 in hamster models

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.

Impaired functional connectivity of the hippocampus in murine models of NMDA-receptor antibody associated pathology

This study investigates functional connectivity changes in murine models of NMDAR antibody-associated pathology using rs-fMRI, finding impaired connectivity in hippocampal regions similar to human patients.

Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model

This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.

Brain Antibody Sequence Evaluation (BASE): an easy-to-use software for complete data analysis in single cell immunoglobulin cloning

BASE is a software tool for analyzing single-cell immunoglobulin cloning data, providing automated analysis with high accuracy and additional plasmid sequence confirmation.