Sukhvir K. Wright

Entropy of the resting state cortex in epilepsy

This study finds that recurrent seizures in epilepsy are associated with reduced cortical entropy in the interictal state, particularly in those with earlier seizure onset.

Peripherally derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model

This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.

NMDA-receptor antibodies alter cortical microcircuit dynamics

This study shows NMDA-receptor antibodies alter cortical microcircuit dynamics and predispose to paroxysmal EEG abnormalities in a mouse model.