Divya Dhangar

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.