Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma
Piyush K. Joshi, Patricia Benites Goncalves da Silva, Konstantin Okonechnikov, Tamina Stelzer, Ioannis Sarropoulos, Mari Sepp, Jana Nolle, Mischan Vali Pour-Jamnani, Anne Rademacher, Tetsuya Yamada-Saito, Celine Schneider, Julia Schmidt, Luca Bianchini, Philipp Sven Lars Schäfer, Kevin Leiss, , Lena M. Kutscher
This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.
bioRxiv · Feb 9, 2024 · PreprintCancer Biology