Kevin Leiss

The evolution of gene regulation in mammalian cerebellum development

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

The regulatory landscape of cells in the developing mouse cerebellum

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

A novel essential RNA-binding protein complex in Trypanosoma brucei

The paper identifies a novel RNA-binding protein complex in Trypanosoma brucei and shows its role in mRNA translation and quality control.

The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei

This paper identifies ERBP1 and ERBP2 as ER-associated mRNA-binding proteins in T. brucei that interact and bind ribosomal protein mRNAs, but not secreted protein mRNAs or stress granules.