A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL
Komal Mandleywala, Simona Ulrich, Victoria da Silva-Diz, Puneet Sharma, Christopher Thai, Oekyung Kim, Maya Aleksandrova, Gwendolyn Chung, Cristián Eggers, D. Luetjohann, Tanaya Kulkarni, Amartya Singh, M. Elena Díaz-Rubio, Michael Wierer, Sebastian A. Leidel, , Daniel Herranz
This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.
bioRxiv · Dec 23, 2025 · PreprintCancer Biology