Localized calcium accumulations prime synapses for phagocyte removal in cortical neuroinflammation
Mehrnoosh Jafari, Adrian-Minh Schumacher, Nicolas Snaidero, Tradite Neziraj, Emily M. Ullrich Gavilanes, Tanja Jürgens, Juan Daniel Flórez Weidinger, Stephanie S. Schmidt, Eduardo Beltrán, Nellwyn Hagan, Lisa A. Woodworth, Dimitry Ofengeim, Joseph Gans, Fred Wolf, Mario Kreutzfeldt, , Martin Kerschensteiner
The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.
bioRxiv · Sep 4, 2019 · PreprintNeuroscience