Eduardo Beltrán

A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimers Disease

The paper identifies region- and disease-specific transcriptomic changes in oligodendrocytes from Alzheimer's disease patients using single-nucleus RNA sequencing.

Localized calcium accumulations prime synapses for phagocyte removal in cortical neuroinflammation

The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

The paper identifies DNA methylation differences in monozygotic twins discordant for multiple sclerosis, highlighting treatment effects and genetic confounders.