Multi-omic profiling reveals impaired luteal resolution and CHK2-regulated inflammation in ovarian aging
Liubin Yang, Zhongwei Sun, Xinlong Luo, Carolina Leynes, Isabel Lorenzo, Ashley Pawelka, Meaghan Donahue, Mancy Tong, Hugh Stott Taylor, Yongqing Zhang, Brendan Lee, TAO P WU, Jason D. Heaney
This study identifies impaired luteal resolution and CHK2-regulated inflammation as features of ovarian aging in mice, showing that CHK2 inhibition can reverse these effects.
bioRxiv · Oct 1, 2026 · PreprintMolecular Biology