Yanyan Qi

This study identifies the role of Hippo signaling in regulating cuticle pigmentation and dopamine metabolism in Drosophila through genetic and transcriptomic analyses.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study presents a single-nucleus transcriptomic atlas of Drosophila treated with rapamycin, identifying a sex-biased convergent aging trajectory and its modulation by rapamycin.

This study identifies Tet as a critical regulator of intestinal stem cell establishment and homeostasis through single-nucleus transcriptomic analysis.

The paper presents a single-nucleus RNA sequencing atlas of Aedes aegypti mosquitoes, identifying novel cell types and sexual dimorphism in gene expression across tissues.

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

This study shows that oncogenic RasV12 activates Dorsal/NF-κB signaling, promoting tumor growth and malignancy in Drosophila melanogaster tumors.

This study shows that TFEB-v-ATPase signaling regulates lysosomal function and microglial activation in tauopathy by impairing lysosomal acidification and altering microglia responses.

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.

The paper investigates biomechanical and molecular mechanisms underlying proprioceptor diversity in Drosophila legs, identifying a biomechanical basis for joint angle selectivity and a goniotopic map of joint angle.

This study shows XIST is required in adult human B cells to silence X-linked immune genes and identifies TRIM28 as a B cell-specific XIST cofactor involved in X-inactivation and atypical B cell formation.

Aedes aegypti olfactory neurons often co-express OR, IR and sometimes GR receptors; in the maxillary palp, one neuron type responds to odorants via both OR and IR pathways.

The paper uses scATAC-seq to analyze chromatin accessibility in immune cell development and tumor microenvironments, identifying regulatory elements and trajectories associated with cell differentiation and therapy response.

EMBLEM uses mitochondrial DNA mutations in ATAC-seq data to track cell lineage with high sensitivity and specificity in acute myeloid leukemia.

Perturb-ATAC combines CRISPR perturbations with single-cell ATAC-seq to identify gene regulatory networks in human cells.

This study investigates the role of Polycomb recruitment in Xist-mediated X chromosome silencing in mouse ES cells, finding that silencing can occur independently of Polycomb complexes.