Hongjie Li

This study identifies the role of Hippo signaling in regulating cuticle pigmentation and dopamine metabolism in Drosophila through genetic and transcriptomic analyses.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study presents a single-nucleus transcriptomic atlas of Drosophila treated with rapamycin, identifying a sex-biased convergent aging trajectory and its modulation by rapamycin.

This study identifies Tet as a critical regulator of intestinal stem cell establishment and homeostasis through single-nucleus transcriptomic analysis.

The paper shows that injured Drosophila gut polyploid enterocytes dedifferentiate into diploid progenitors via paligenosis, involving autophagy and TORC1.

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

The paper presents a single-nucleus RNA sequencing atlas of Aedes aegypti mosquitoes, identifying novel cell types and sexual dimorphism in gene expression across tissues.

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

The paper shows that dimensionality reduction simplifies synaptic partner matching in the fly antennal lobe by reducing a 3D search problem to a 1D trajectory.

This study identifies the intracellular signaling pathway of teneurins in synaptic partner matching using Drosophila models.

The paper identifies COPD risk genes using Drosophila melanogaster, validating their role in epithelial barrier function through nAchR signaling in the gut.

This study shows that TFEB-v-ATPase signaling regulates lysosomal function and microglial activation in tauopathy by impairing lysosomal acidification and altering microglia responses.

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.

The paper provides single nucleus and single cell RNA-seq data from Drosophila testes to study spermatogenesis, identifying rare cell types and developmental transitions.

The paper investigates biomechanical and molecular mechanisms underlying proprioceptor diversity in Drosophila legs, identifying a biomechanical basis for joint angle selectivity and a goniotopic map of joint angle.

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

The paper maps chemosensory co-receptor expression in Drosophila olfactory neurons, revealing widespread co-expression patterns among Orco, Ir25a, Ir8a, and Ir76b.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper characterizes cell types in the fly kidney using snRNA-seq and identifies new clusters, markers, and signaling networks, linking them to mammalian and planarian kidney structures.

The paper generates single-cell transcriptomes of Drosophila olfactory receptor neurons across development and adulthood, revealing stable receptor expression and cell-type-specific transcriptomic features.

The paper analyzes single-cell transcriptomes of Drosophila olfactory projection neurons across developmental stages to identify transcriptomic changes and cellular diversity patterns.

The paper uses time-lapse imaging in Drosophila to study how olfactory receptor neurons target axons to specific glomeruli, revealing dynamics of branching and bilateral interactions.

Aedes aegypti olfactory neurons often co-express OR, IR and sometimes GR receptors; in the maxillary palp, one neuron type responds to odorants via both OR and IR pathways.

The paper profiles cell-surface proteomes in Drosophila olfactory neurons across development, identifying new regulators of neural circuit assembly.

This paper identifies Fish-lips (Fili) as a transmembrane protein that mediates repulsion between non-synaptic partner neurons to ensure precise wiring in the Drosophila olfactory circuit.

The paper identifies transcription factors that coordinate olfactory receptor expression and wiring specificity in Drosophila ORNs using single-cell RNA-sequencing and genetic analysis.

This study uses single-cell RNA sequencing to classify Drosophila olfactory projection neuron subtypes and identifies key transcription factors and molecular codes involved in their specification.