Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation.
Gregory Nagy, Rebecca Presley, Hyeongseon Jeon, Lynn Moreira, Shruti Dhar, Olivia Tull, Burak Soysal, Anika S. Yadati, Kayleigh D. Cook, Laura E. Schnell, Arkobrato Gupta, Tapahsama Banerjee, Dongjun Chung, Philip N. Tsichlis, Jeffrey D. Parvin
The paper functionally screens TAP2 variants to show PLK1 overexpression reduces MHC-I surface abundance by phosphorylating TAP2, impairing antigen presentation in cancer cells.
bioRxiv · Sep 30, 2024 · PreprintCancer Biology