Author

Philip N. Tsichlis

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0002-5300-0448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alessandro La FerlitaiD· 2 shared Arkobrato GuptaiD· 2 shared Burak SoysaliD· 2 shared Dongjun ChungiD· 2 shared Gregory NagyiD· 2 shared Hyeongseon JeoniD· 2 shared Jeffrey D. ParviniD· 2 shared Lynn Moreira· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Alessandro La FerlitaORCID

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4 papers

Recent·Most cited

Identification of TAP2 protein variants resistant to inhibition by the HSV1 ICP47 protein

Gregory Nagy, Rebecca Presley, Shruti Dhar, Hyeongseon Jeon, Lynn Moreira, Olivia Tull, Arkobrato Gupta, Dongjun Chung, Philip N. Tsichlis, Jeffrey D. Parvin

The paper identifies TAP2 protein variants resistant to HSV1 ICP47 inhibition, which could lead to new antiviral therapies.

bioRxiv · Nov 18, 2024 · PreprintImmunology

Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation.

Gregory Nagy, Rebecca Presley, Hyeongseon Jeon, Lynn Moreira, Shruti Dhar, Olivia Tull, Burak Soysal, Anika S. Yadati, Kayleigh D. Cook, Laura E. Schnell, Arkobrato Gupta, Tapahsama Banerjee, Dongjun Chung, Philip N. Tsichlis, Jeffrey D. Parvin

The paper functionally screens TAP2 variants to show PLK1 overexpression reduces MHC-I surface abundance by phosphorylating TAP2, impairing antigen presentation in cancer cells.

bioRxiv · Sep 30, 2024 · PreprintCancer Biology

KDM2B is required for ribosome biogenesis and its depletion unequally affects mRNA translation

Vollter Anastas, Evangelia Chavdoula, Alessandro La Ferlita, Burak Soysal, Ilaria Cosentini, Giovanni Nigita, Michael G. Kearse, Philip N. Tsichlis

This study shows KDM2B promotes ribosome biogenesis by enhancing transcription of ribosome-related genes and affects mRNA translation unequally based on mRNA features.

bioRxiv · May 22, 2024 · PreprintCancer Biology

PHENSIM: Phenotype Simulator

Salvatore Alaimo, Rosaria Valentina Rapicavoli, Gioacchino P. Marceca, Alessandro La Ferlita, Oksana B. Serebrennikova, Philip N. Tsichlis, Bud Mishra, Alfredo Pulvirenti, Alfredo Ferro

PHENSIM simulates cell phenotype changes due to biomolecule activation/inhibition using signaling pathways, showing high prediction accuracy through benchmarking.

PLoS Computational Biology · Jun 24, 2021Peer-reviewedBioinformatics