Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation.
Gregory Nagy, Rebecca Presley, Hyeongseon Jeon…·Jeffrey D. Parvin
The paper functionally screens TAP2 variants to show PLK1 overexpression reduces MHC-I surface abundance by phosphorylating TAP2, impairing antigen presentation in cancer cells.