Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging
Jana Svobodova Burianova, Jan Svoboda, Jiří Růžička, Kateřina Štěpánková, Tereza Klausová, Lenka Gmiterková, Tereza Spundova, Noelia Martínez-Varea, Michaela Králíková, Rostislav Tureček, Lucia Machová Urdzíková, James W. Fawcett, Pavla Jendelová, Jessica C. F. Kwok
This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.
bioRxiv · Jan 29, 2026 · PreprintNeuroscience