Pavla Jendelová

4-Methylumbelliferone Restores Age-Related Changes in Perineuronal Nets, Memory and Neuroinflammation

This study shows that 4-MU reduces PNNs, improves memory, and decreases neuroinflammation in aged mice.

Intertwined Autophagy and Integrin Dynamics Shape Axon Growth and Regeneration

This study investigates the relationship between autophagy and integrin dynamics in axon growth and regeneration, finding a bidirectional feedback system that regulates these processes.

Modular in vitro evaluation of Buparlisib-polymeric nanomedicines in 2D and 3D models of glioblastoma

This study evaluates Buparlisib-polymeric nanomedicines in 2D and 3D glioblastoma models, finding that redox-sensitive conjugates show better activity than azide-based ones.

Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

Long-Term Expression and Safety of AAV1-Mediated PI3Kδ Overexpression in the Adult Rat Cortex

This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.

Dibutyryl cyclic AMP downregulates tenascin-C in neurons and astrocytes and reduces AAV-mediated gene expression in DRG neurons

This study investigates the combined effects of db-cAMP and integrin 9 overexpression on axonal regeneration in spinal cord injury models, finding mixed in vitro and in vivo results.

Dizocilpine derivatives with neuroprotective effect lacking the psychomimetic side effects

This study develops novel NMDA receptor antagonists with neuroprotective effects and reduced psychomimetic side effects through structural modifications of MK-801.

Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program

This study identifies a distinct CNS regeneration program activated by integrin expression in spinal cord sensory neurons, differing from PNS regeneration and involving ubiquitination, autophagy, and signaling pathways.

Alpha 9 integrin expression enables reconstruction of the spinal cord sensory pathway.

This paper demonstrates that expressing alpha 9 integrin and its activator kindlin-1 in sensory neurons enables axon regeneration through spinal cord injuries in rats, restoring sensory function.

Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity

This study evaluates the effect of 4-MU on spinal cord injury in rats, showing reduced HA synthesis and glial scar but insufficient functional recovery.

4-methylumbelliferone enhances neuroplasticity in the central nervous system: potential oral treatment for SCI

This study shows that 4-MU removes perineuronal nets and enhances plasticity in the central nervous system, offering a potential oral treatment for spinal cord injury.

Perineuronal nets affect memory and learning after synapse withdrawal

This study examines the role of perineuronal nets (PNNs) in memory and learning after synaptic withdrawal induced by an hibernation-like state, finding that PNN absence affects synaptic restoration but not long-term memory storage.