Author

Noelia Martínez-Varea

Czech Academy of SciencesORCID 0000-0002-0775-1734Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Organism:rat· 1

Frequent Co-Authors

Jessica C. F. KwokiD· 4 shared Lucia Machová UrdzíkováiD· 4 shared Pavla JendelováiD· 4 shared Kateřina ŠtěpánkováiD· 3 shared James W. FawcettiD· 2 shared Anda CimpeaniD· 1 shared Dana Mareková· 1 shared Jan SvobodaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersNeuroscience

Jessica C. F. KwokORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

4-Methylumbelliferone Restores Age-Related Changes in Perineuronal Nets, Memory and Neuroinflammation

Anda Cimpean, Jana Dubišová, Noelia Martínez-Varea, Dana Mareková, Lucia Machová Urdzíková, James W. Fawcett, Pavla Jendelová, Jessica C. F. Kwok

This study shows that 4-MU reduces PNNs, improves memory, and decreases neuroinflammation in aged mice.

Glia · Sep 30, 2026Peer-reviewedNeuroscience

Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging

Jana Svobodova Burianova, Jan Svoboda, Jiří Růžička, Kateřina Štěpánková, Tereza Klausová, Lenka Gmiterková, Tereza Spundova, Noelia Martínez-Varea, Michaela Králíková, Rostislav Tureček, Lucia Machová Urdzíková, James W. Fawcett, Pavla Jendelová, Jessica C. F. Kwok

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

bioRxiv · Jan 29, 2026 · PreprintNeuroscience

Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity

Kateřina Štěpánková, Milada Chudíčková, Zuzana Šimková, Noelia Martínez-Varea, Šárka Kubinová, Lucia Machová Urdzíková, Pavla Jendelová, Jessica C. F. Kwok

This study evaluates the effect of 4-MU on spinal cord injury in rats, showing reduced HA synthesis and glial scar but insufficient functional recovery.

bioRxiv · Feb 2, 2023 · PreprintNeuroscience

4-methylumbelliferone enhances neuroplasticity in the central nervous system: potential oral treatment for SCI

Sîan F. Irvine, Sylvain Gigout, Kateřina Štěpánková, Noelia Martínez-Varea, Lucia Machová Urdzíková, Pavla Jendelová, Jessica C. F. Kwok

This study shows that 4-MU removes perineuronal nets and enhances plasticity in the central nervous system, offering a potential oral treatment for spinal cord injury.

bioRxiv · Jan 23, 2023 · PreprintNeuroscience