Jan Svoboda

Partial lesions of hypocretin neurons of the rat lateral hypothalamus affect wake and sleep regulation under increased sleep pressure

This study examines how partial lesions of hypocretin neurons in rats affect sleep regulation under increased sleep pressure, finding accelerated slow wave sleep and reduced theta frequency.

Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

PV+ optogenetic stimulations at specific frequencies in specific brain regions can restore navigational flexibility in an acute MK801 mouse model of schizophrenia

The paper investigates how frequency-specific optogenetic stimulation of PV+ interneurons in mPFC and vHPC can restore navigational flexibility in an acute MK801 mouse model of schizophrenia.

CA1 ensemble plasticity is coupled to context change and modulated by task familiarity

The paper investigates how context change and task familiarity affect CA1 IEG+ ensembles in rats, finding that ensemble size reflects uncertainty and task demands.

The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK801 model of schizophrenia-like cognitive inflexibility

This study investigates how optogenetic stimulation of parvalbumin-positive interneurons in the prefrontal cortex and ventral hippocampus can rescue cognitive inflexibility induced by dizocilpine in rats.