I. Ahmed

Mice Models to Bioinformatics Methods Led to the Discovery of Antidiabetic Compounds in the F. racemosa Plant Extracts

The paper uses animal models and in silico experiments to identify antidiabetic compounds in Ficus racemosa extracts, finding four compounds with potential therapeutic effects.

In vivo and in silico experiment on Mitragyna speciosa offers new insight of antidiabetic potentials

This study investigates the anti-diabetic potential of Mitragyna speciosa using in vivo and in silico methods, finding that extracts reduce blood glucose levels and four compounds bind effectively to the DPP4 receptor.

Clonal fitness decline in somatic differentiation hierarchies

The paper shows clonal fitness declines over time in somatic differentiation hierarchies, observable in human haematopoiesis and CLL, with a 1/time relationship and equilibrium fitness.

GAGA zinc finger transcription factor searches chromatin by 1D-3D facilitated diffusion

This study tracks GAF's chromatin search mechanism using smFRET and imaging, showing 1D-3D diffusion enables efficient target finding despite nucleosome barriers.

Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma

This study identifies AP-1 as a key transcription factor mediating ERBB2-driven mesenchymal-like properties in oesophageal adenocarcinoma through integrated phosphoproteomics, open chromatin profiling, and transcriptome analysis.

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

The paper identifies enhancer RNAs in oesophageal adenocarcinoma using RNA-seq and open chromatin maps, revealing new deregulated pathways and their clinical relevance.

Honey bee flights under ethanol-exposure show changes in body and wing kinematics

This study quantifies changes in honey bee flight kinematics under ethanol exposure, identifying body and wing motion alterations at different concentrations.

High Speed Visual Insect Swarm Tracker (Hi-VISTA) used to identify the effects of confinement on individual insect flight

Hi-VISTA tracks insect flight dynamics in confined and unconfined environments, showing confinement affects body pitch, heading rate, flapping frequency, and vertical speed.

Pseudogenization of trnT-GGU in chloroplast genomes of the plant family Asteraceae

The paper identifies pseudogenization of the trnT-GGU gene in three Asteraceae subfamilies, showing it is linked to a 5' acceptor stem insertion, not plant habit or geography.

The GASA Gene Family in Theobroma cacao: Genome Wide Identification and Expression Analyses

This study identifies and analyzes 17 GASA genes in Theobroma cacao, showing their expression in seeds and differential response to fungal infection.

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Comparison among the first representative chloroplast genomes of Orontium, Lasia, Zamioculcas, and Stylochaeton of the plant family Araceae: inverted repeat dynamics are not linked to phylogenetic signaling

The paper compares chloroplast genomes of four Araceae genera, finding inverted repeat dynamics are homoplasious and not useful for phylogenetic analysis.

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

TGF-β Mediated Cell Adhesion Dynamics and Epithelial to Mesenchymal Transition in 3D and 2D Ovarian Cancer Models

This study compares 3D and 2D ovarian cancer models to show TGF-β induces EMT, invasion, and aggressiveness, with reversible effects using a TGF-β inhibitor.

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes

This study identifies circANKRD12 as a circular RNA that promotes cancer invasion by regulating cell cycle, migration, and metabolism when silenced.

DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

The paper shows DET1 regulates H2Bub homeostasis in Arabidopsis by controlling the stability of a DUBm through interaction with DDA1.