David Barford

The paper identifies a conserved interaction between Bim1 and the Ndc80 complex in S. cerevisiae, showing it enhances microtubule attachment strength and is regulated by phosphorylation.

This study identifies a conserved interaction between Bim1 and the Ndc80 complex in S. cerevisiae, showing it enhances microtubule attachment strength and is regulated by phosphorylation.

This study uses cryo-EM to reveal structural mechanisms of KMN complex assembly and phospho-regulation in budding yeast kinetochores.

This study identifies a bipartite mechanism for condensin II activation in mitosis, showing how M18BP1 relieves autoinhibition and enables DNA loop formation.

The paper determines cryo-EM structures of the CCAN complex bound to different DNA sequences to understand its architecture on centromeric α-satellite CENP-A nucleosome arrays.

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

This study elucidates how the Cdc20MIM induces Mad2 conformational conversion by transiently exposing a binding site and facilitating structural changes.

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.

This study compares cryo-EM structures of S. cerevisiae and human APC/C complexes, revealing conserved architectures and differences in regulatory mechanisms.

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.