Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine
Samantha G. Muccilli, Benjamin H. Schwarz, Byron Shue, Forrest Jessop, Jeffrey G. Shannon, Charles L. Larson, Adam Hage, Seon-Hui Hong, Eric Bohrnsen, Thomas Hsu, Alison W. Ashbrook, Gail L. Sturdevant, Shelly J. Robertson, Joseph W. Guarnieri, Justin Lack, , Sonja M. Best
This study identifies mitochondrial hyperactivity and reactive oxygen species as critical drivers of innate immunity to the YFV-17D vaccine, enhancing IFN response and vaccine effectiveness.
PLoS Pathogens · Apr 21, 2025Peer-reviewedImmunology