Engineering BCMA CAR T cells for myeloma-targeted cargo delivery
Thomas Kimman, Marta Cuenca, Ralph Geoffrey Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D. Meringa, Wendy Boschloo, Douwe M. T. Bosma, Sanne Kroos, Vania Lo Presti, Joost P. G. Sluijter, , Victor Peperzak
This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.
Nature Communications · May 19, 2025Peer-reviewedImmunology