Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
Constantinos Patinios, Darshana Gupta, Harris V. Bassett, Scott P. Collins, Charlotte Kamm, Anuja Kibe, Yanyan Wang, Chengsong Zhao, Katie Vollen, Christophe Toussaint, Kathryn M. Polkoff, Thuan Nguyen, Irene Calvin, Angela Migur, Ibrahim S. Al’Abri, , Chase L. Beisel
This paper introduces append editing, a method that uses ADP-ribosylation to achieve distinct genome editing outcomes in bacteria and eukaryotes.
bioRxiv · Nov 17, 2024 · PreprintSynthetic Biology