Ibrahim S. Al’Abri

This study develops an E. coli strain with enhanced plasmid DNA production through genome-wide mutagenesis and identifies key genetic factors contributing to increased plasmid copy numbers.

This paper introduces append editing, a method that uses ADP-ribosylation to achieve distinct genome editing outcomes in bacteria and eukaryotes.

This study engineers S. boulardii to control gene expression and gut residence time via diet-responsive systems, enabling precise therapeutic delivery in the mouse gut.

This paper improves therapeutic protein secretion in Saccharomyces boulardii using genetic modifications and proteomics, achieving >10-fold higher secretion of a neutralizing peptide.

The paper introduces a method to evolve complex bacterial phenotypes using inducible directed evolution, achieving faster growth on tagatose after two rounds of evolution.

This paper characterizes genetic elements in Saccharomyces boulardii to enable engineered biomolecule synthesis and delivery in the gut, showing tunable gene expression and colonization dynamics.