NeurosciencebioRxivPreprint
Activity-dependent LTP in the dentate gyrus promotes epileptic seizures
Kaoutsar Nasrallah, M. Agustina Frechou, Young J. Yoon…·Pablo E. Castillo
The paper shows that initial seizures in mice increase mossy cell-granule cell synaptic transmission via BDNF-dependent LTP, which worsens seizures and suggests a mechanism for epileptogenesis.
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