Designed allosteric biosensors for engineered T cell therapy of cancer
Jan A. Rath, Lucas S. P. Rudden, Nazila Nouraee, Tiffany Que, Christine Von Gunten, Cynthia Pérez, Flora Birch, Yashashvi Bhugowon, Andreas Füglistaler, Aisima Chatzi Souleiman, Patrick Barth, Caroline Arber
This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.
bioRxiv · Mar 14, 2025 · PreprintBioengineering