Srinivas Koutarapu

Distribution of big tau isoforms in the human central and peripheral nervous system

The paper characterizes big tau isoforms in human nervous system tissues and CSF, finding they are enriched in the peripheral nervous system and largely unaffected by neurodegenerative disease.

Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer's Neuropathology

The paper presents a spatial multi-omics workflow for Alzheimer's neuropathology, resolving spatially distinct molecular domains and establishing analytical guidelines.

Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques

The paper identifies differences in post-translational modifications of amyloid-β isoforms between vascular deposits and parenchymal plaques in Alzheimer's disease.

Isotope Encoded Chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

Chemical imaging signatures delineate heterogeneous amyloid plaque populations across the Alzheimers disease spectrum

This study uses chemical imaging and deep learning to identify distinct amyloid plaque subtypes in Alzheimer's disease, revealing differences in Aβ composition and associations with disease progression.