NF-κB transcriptionally enhances p53 accumulation dynamics hampering DNA repair
Emanuele Colombo, Sara Pozzi, Alessia Loffreda, Francesca Genova, Erika Aloi, Timothy Heinichen, Paola Falletta, Matteo Mazzocca, Tom Fillot, Daniela Gnani, A Agresti, Marco Emilio Bianchi, Samuel Zambrano, Davide Mazza
This study investigates how NF-κB co-activation enhances p53 accumulation dynamics, impairing DNA repair and revealing a transcriptionally mediated antagonism between p53 and NF-κB.
bioRxiv · Feb 25, 2026 · PreprintSystems Biology