Synthesis and characterization of 5-(2-fluoro-4-pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2
Gengyang Yuan, Maëva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Hao Wang, Sung‐Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, , Anna‐Liisa Brownell
The paper develops and characterizes [11C]13, a PET ligand for mGluR2, showing its brain distribution and response to mGluR2 NAMs in rats and nonhuman primates.
Journal of Medicinal Chemistry · Jan 28, 2022Peer-reviewedNeuroscience