Author

Manish Kumar Jain

University of North Carolina at Chapel HillORCID 0000-0001-8173-3326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Organism:non-human primate· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Anna‐Liisa BrownelliD· 2 shared Dalena HuynhiD· 2 shared Gengyang YuaniD· 2 shared Georges El FakhriiD· 2 shared Hye Jin KangiD· 2 shared Julie E. PickettiD· 2 shared Maëva DhaynautiD· 2 shared Marc D. NormandiniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Anna‐Liisa BrownellORCID

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4 papers

Recent·Most cited

Pharmacology & ToxicologyBiochemistryPeer-reviewedMar 20, 2025

Functionally selective dopamine D1 receptor endocytosis and signaling by catechol and non-catechol agonists

Ashley N. Nilson, Daniel Eric Felsing, Pingyuan Wang…·John A. Allen

This paper investigates how catechol and non-catechol dopamine D1 receptor agonists induce different signaling and endocytosis patterns, showing that functional selectivity impacts receptor internalization.

4 citations

humanexperimental assay

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NeuroscienceJournal of Medicinal ChemistryPeer-reviewedJul 8, 2022

Design, synthesis, and characterization of mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2

Gengyang Yuan, Maëva Dhaynaut, Nicolas J. Guehl…·Anna‐Liisa Brownell

The paper describes the synthesis and characterization of [18F]mG2P026 as a PET ligand for mGluR2, showing improved brain permeability and binding compared to existing compounds.

8 citations

ratnon-human primate

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NeuroscienceJournal of Medicinal ChemistryPeer-reviewedJan 28, 2022

Synthesis and characterization of 5-(2-fluoro-4-pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2

Gengyang Yuan, Maëva Dhaynaut, Yu Lan…·Anna‐Liisa Brownell

The paper develops and characterizes [11C]13, a PET ligand for mGluR2, showing its brain distribution and response to mGluR2 NAMs in rats and nonhuman primates.

5 citations

ratnon-human primate

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NeurosciencebioRxivPreprintDec 9, 2021

Pharmacologic analysis of non-synonymous coding 5-HT2A SNPs reveals alterations psychedelic drug potencies and efficacies

Gavin P. Schmitz, Manish Kumar Jain, Samuel T. Slocum, Bryan L. Roth

The paper examines how non-synonymous SNPs in the 5-HT2A receptor gene affect the potency and efficacy of four psychedelic drugs in vitro.

DOI 10.1101/2021.12.09.472000

humanstatistical model

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