Evolutionary analysis implicates RNA polymerase II pausing and chromatin structure in nematode piRNA biogenesis
Toni Beltran, Cristina Barroso, Timothy Y. Birkle, Lewis Stevens, Hillel T. Schwartz, Paul W. Sternberg, Hèléne Fradin, Kristin C. Gunsalus, Fabio Piano, James Anthony Cotton, Enrique Martínez-Pérez, Mark Blaxter, Peter Sarkies
The paper investigates piRNA biogenesis in nematodes, showing that piRNA upstream motifs are derived from snRNA promoter elements and that piRNA production depends on RNA polymerase II pausing and chromatin structure.
bioRxiv · Mar 13, 2018 · PreprintGenomics