Paul W. Sternberg

The paper presents a chromosome-level genome assembly of Panagrellus redivivus, enabling comparative studies of parasitism evolution by providing a non-parasitic reference genome.

The paper identifies methyl 3-methyl-2-butenoate (MMB) as a male-derived volatile sex pheromone in nematodes, showing it is attractive to females and hermaphrodites and mimics a predator's chemical cues.

The paper identifies srh-30 as a receptor for 2-nonanone in C. elegans using single-cell expression data and genetic validation.

The scFAIR Consortium develops a unified metadata schema and portal to improve FAIRness of scRNA-seq data through standardized annotations and semantic search.

This paper develops a single-molecule fluorescence in situ hybridization workflow for whole-organism spatial transcriptomics in C. elegans, enabling single-cell resolution and multiplex gene profiling.

This paper shows that C. elegans males use an antagonistic sensory system to navigate pheromone gradients, with head and tail neurons having opposing roles in movement control.

This study identifies cyclohexyl acetate as a volatile sex pheromone mimic in Caenorhabditis nematodes, showing it acts as a male-specific attractant through a distinct sensory pathway.

The paper identifies four O-acetyltransferase genes in C. elegans essential for synthesizing volatile sex pheromones and reveals their dual role in producing both volatile and non-volatile pheromone components.

The paper identifies gas-sensing neurons and characterizes calcium responses in ASI and AIA neurons to understand dauer entry decision-making in C. elegans.

Synaptic MEMOIR maps individual synapses in neuronal projections using protein barcodes, enabling single-synapse resolution in large brain volumes without high-resolution imaging.

The paper introduces k-spaces, a probabilistic framework for simultaneous dimension reduction, clustering, and latent space learning, demonstrating its application in genomic settings.

This study investigates the evolution of parasitism-related traits in nematodes, finding that entomopathogenic nematodes have lost hatchling survival traits and can develop without symbiotic bacteria.

The paper presents the genome of Steinernema hermaphroditum and its associated bacteria, revealing gene clusters and a potential second bacterial circle in entomopathogenic nematodes.

This study identifies a role for FKH-7/FOXP in chemosensory neurons regulating developmental decision-making and links it to autism-associated gene variants.

The paper develops sentence classification models to identify biocuration-relevant sentences for gene expression and protein kinase activity from scientific literature, achieving high F1 scores with GPT and BioBERT.

The paper introduces FHR, a metadata standard for reference genome data to improve interoperability and data provenance tracking across platforms.

This study identifies how insulin-like peptide signaling in C. elegans ASJ neurons integrates sensory cues for dauer exit decision-making.

The paper uses single-tissue proteomics in C. elegans to identify proteins in intestinal lysosome-related organelles, revealing novel components and interorgan protein transport.

The paper identifies a peroxidase gene controlling body size in Steinernema hermaphroditum using whole-genome re-sequencing and CRISPR-Cas9 validation.

The paper updates the Alliance of Genome Resources' central infrastructure, adding tools and enhancing data management and curation capabilities.

The paper develops CeN-CAM, a semantic model based on GO-CAM, to represent causal relationships in C. elegans neural circuits and behaviors using literature data.

This study uses single-nucleus RNA-seq to map the adult C. elegans transcriptome and assess inter- and trans-generational effects of alcohol exposure at cell type resolution.

The paper shows that distinct neural circuits in C. elegans mediate the same CO2 attraction behavior at different life stages, with insulin signaling modulating these circuits.

The paper identifies new interactors of LINKIN (ITFG1) and shows their role in cell migration and tissue integrity in C. elegans and human breast cancer cells.

The paper investigates the roles of PEZO-1 and TRP-4 mechanosensors in C. elegans mating behavior, showing their involvement in multiple mating steps and mechanosensory functions.

The paper identifies neuropeptidergic pathways in C. elegans that mediate developmental decisions between reproductive growth and diapause based on pheromone cues.

The paper shows that a steroid hormone pathway regulates both entry into and exit from dauer diapause in C. elegans, with similar spatiotemporal dynamics for both processes.

The paper introduces two web apps for analyzing single-cell RNA sequencing data with C. elegans datasets from WormBase.

The paper identifies sex-specific receptor expression in C. elegans olfactory neurons and shows their non-redundant role in ascr#8 sensing.

The paper identifies Steinernema hermaphroditum CS34 as a self-fertilizing hermaphrodite with genetic tractability for studying symbiosis and parasitism.