Toni Beltran

Energy-model maps of five human kinases show conserved distance-dependent decay of inhibitory allostery, but distal allosteric pockets and activating sites diverge between kinases.

This paper presents a method to identify allosteric sites in enzymes and applies it to Src kinase, producing the first comprehensive map of its allosteric control.

This study shows that natural selection in C. elegans maintains low TE expression, with increased TE expression observed in smaller populations due to reduced silencing efficiency.

The paper shows that the Integrator complex cleaves nascent piRNA precursors to terminate promoter-proximal Pol II transcription in C. elegans.

This study identifies RPB-9 as essential for piRNA-mediated silencing in C. elegans by promoting transcriptional elongation/termination at piRNA loci.

This study investigates epimutations driven by small RNAs in C. elegans, finding they arise frequently but have limited duration.

The paper describes ten new Caenorhabditis species, presents their genome sequences, and analyzes their evolutionary relationships and gene structure.

The paper investigates piRNA biogenesis in nematodes, showing that piRNA upstream motifs are derived from snRNA promoter elements and that piRNA production depends on RNA polymerase II pausing and chromatin structure.