Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2'-deoxy-cytidine antimetabolite
Maike Däther, Elsa Peev, Anna Sophie Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiß, Corinna C. Pleintinger, Emmanuel A. Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, , Thomas Carell
This study shows that the carbocyclic antimetabolite cAzadC increases TET2 expression and 5hmdC levels, leading to reactivation of anti-tumor responses in AML models.
Angewandte Chemie · Jun 21, 2026Peer-reviewedCancer Biology