Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Ly-Sha Ee, Daniel Medina-Cano, Christopher M. Uyehara, Clayton Schwarz, Emily Goetzler, Eralda Salataj, Alexander Polyzos, Subhashini Madhuranath, Todd Evans, Anna‐Katerina Hadjantonakis, Effie Apostolou, Tommy Vierbuchen, Matthias Stadtfeld
This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.
bioRxiv · May 30, 2024 · PreprintDevelopmental Biology