Ly-Sha Ee

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.

Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression

Context-dependent requirement of H3K9 methyltransferase activity during cellular reprogramming to iPSCs

This study shows that reducing EHMT1/2 activity during reprogramming with ascorbic acid impairs iPSC formation and viability, highlighting the role of H3K9 methylation in reprogramming efficiency.