Daniel Medina-Cano

The paper develops a mouse cortical organoid platform to study cis-regulatory evolution and identifies genes with dynamic allelic imbalances during neurogenesis.

This paper develops a protocol to efficiently generate tissue-resident macrophages from mouse pluripotent stem cells, enabling in vitro and in vivo modeling of their development.

This paper establishes a pluripotent stem cell platform using genetically diverse mouse lines to study the impact of natural genetic variation on development and gene regulation.

This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.

The paper presents optimized protocols for generating definitive endoderm and forebrain-patterned neural organoids from mouse epiblast stem cells.

This study identifies MINPP1 mutations as a cause of Pontocerebellar Hypoplasia, showing that MINPP1 deficiency leads to IP6 accumulation and cation chelation, disrupting brain development.