Enlarged Perivascular Spaces are Associated with White Matter Injury, Brain Atrophy, Cognitive Decline and Markers of Inflammation in an Autosomal Dominant Vascular Neurodegenerative Disease (CADASIL)
Nikolaos Karvelas, Bradley C Oh, Earnest Wang, Yann Cobigo, Torie Tsuei, Stephen Fitzsimons, Alexander J. Ehrenberg, Michael D. Geschwind, Daniel Schwartz, Joel H. Kramer, Adam R. Ferguson, Bruce L. Miller, Lisa C. Silbert, Howard J. Rosen, Fanny M. Elahi
This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.
bioRxiv · Aug 17, 2023 · PreprintNeuroscience