Stephen Fitzsimons

NOTCH3 Modulation of Extracellular Matrix, Cytoskeletal Organisation and Metabolic Functions in Human Vascular Smooth Muscle Cells

This study investigates the effects of NOTCH3 suppression in human vascular smooth muscle cells, revealing changes in extracellular matrix, cytoskeletal organization, and metabolic pathways.

Plasma Proteomics of Genetic Brain Arteriosclerosis and Dementia Syndrome Identifies Signatures of Fibrosis, Angiogenesis, and Metabolic Alterations

The paper identifies plasma proteomic signatures associated with CADASIL stages, revealing fibrosis, angiogenesis, and metabolic alterations.

Enlarged Perivascular Spaces are Associated with White Matter Injury, Brain Atrophy, Cognitive Decline and Markers of Inflammation in an Autosomal Dominant Vascular Neurodegenerative Disease (CADASIL)

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

Sexually dimorphic differences in angiogenesis markers predict brain aging trajectories

The paper examines associations between circulating angiogenesis markers and brain aging trajectories in humans, finding sex-specific effects and implications for vascular cognitive impairment.