Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Minsoo Kim, Kwangho Kim, Jesun Lee, Lea A. Barny, Toya D. Scaggs, Ian M. Romaine, KyuOk Jeon, Simona G. Codreanu, Stacy D. Sherrod, JOHN A. JUN. MCLEAN, Anjaparavanda P. Naren, Gary A. Sulikowski, Lars Plate
The paper identifies SCCPDH as an off-target of VX-445 using a photoaffinity ligand and chemoproteomics, showing metabolic dysregulation and potential clinical implications.
ACS Chemical Biology · Jun 20, 2025Peer-reviewedBiochemistry