BiochemistryACS Chemical BiologyPeer-reviewed
Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Minsoo Kim, Kwangho Kim, Jesun Lee…·Lars Plate
The paper identifies SCCPDH as an off-target of VX-445 using a photoaffinity ligand and chemoproteomics, showing metabolic dysregulation and potential clinical implications.
2 citations