SMCHD1's DNA binding activity enables its stable retention on chromatin
Ruifeng Hu, Julissa J. Sánchez‐Velásquez, Jieqiong Lou, Kelsey A. Breslin, Tamara Cameron, Ashleigh N. Solano, Iromi Wickramasinghe, Quentin A. Gouil, Andrew J. Kueh, Tracy Willson, Andrew Keniry, Niall D. Geoghegan, Elizabeth Hinde, Marnie E. Blewitt
This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.
bioRxiv · Sep 20, 2026 · PreprintGenomics