Author

Iromi Wickramasinghe

The University of Melbourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

Kelsey A. BresliniD· 2 shared Marnie E. BlewittiD· 2 shared Quentin A. GouiliD· 2 shared Tamara Cameron· 2 shared Alexandra D. GurzauiD· 1 shared Andrew J. KuehiD· 1 shared Andrew KeniryiD· 1 shared Andrew P. LeisiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Kelsey A. BreslinORCID

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Author profile →

2 papers

Recent·Most cited

SMCHD1's DNA binding activity enables its stable retention on chromatin

Ruifeng Hu, Julissa J. Sánchez‐Velásquez, Jieqiong Lou, Kelsey A. Breslin, Tamara Cameron, Ashleigh N. Solano, Iromi Wickramasinghe, Quentin A. Gouil, Andrew J. Kueh, Tracy Willson, Andrew Keniry, Niall D. Geoghegan, Elizabeth Hinde, Marnie E. Blewitt

This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.

bioRxiv · Sep 20, 2026 · PreprintGenomics

DNA binding by ATPase-adjacent domains stimulates SMCHD1 ATPase activity

Alexandra D. Gurzau, Richard W. Birkinshaw, Andrew P. Leis, Tamara Cameron, Megan Iminitoff, Kelsey A. Breslin, Iromi Wickramasinghe, Samantha Eccles, Hannah Kate Vanyai, Quentin A. Gouil, Peter E. Czabotar, James M. Murphy, Marnie E. Blewitt

This study identifies a second DNA-binding site in SMCHD1 and shows that DNA binding stimulates its ATPase activity, revealing a mechanism for gene silencing.

bioRxiv · Feb 5, 2026 · PreprintBiochemistry