Jieqiong Lou

SMCHD1's DNA binding activity enables its stable retention on chromatin

This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.

Cell cycle dependent regulation of mRNA export in response to replication stress

The paper identifies WEE1, CDK1, and PLK1 as regulators of mRNA export during DNA replication stress, showing their role in preventing R-loop associated mRNA from being exported to the cytoplasm.

MORC2 phosphorylation fine tunes its DNA compaction activity

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation

This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.