Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Miguel A. Medina-Serpas, Maigan Brusko, Gregory J. Golden, Martha Campbell‐Thompson, Trevor Rogers, Shay Reardon, Amanda L. Posgai, Rhonda L. Bacher, Eline T. Luning Prak, C Liu, Klaus H. Kaestner, Ali Naji, Michael R. Betts, Lauren M. McIntyre, Mark A. Atkinson, Todd M. Brusko
This study uses spatial transcriptomics to identify inflammation signatures in pancreas and lymph node tissues of T1D patients, highlighting LTB and other genes involved in disease pathogenesis.
Cell Reports · Mar 23, 2026Peer-reviewedImmunology