Hierarchical assembly and functional resilience of the mammalian RNA exosome
Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch, Elisabeth Roitinger, Johannes A. Zuber, Stefan Ludwig Ameres
The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.
bioRxiv · Mar 14, 2025 · PreprintMolecular Biology