Niko P. Popitsch

This study investigates how uridylation mediates RNA decay in Drosophila by showing how Tailor generates oligo(U) intermediates and how Dis3l2 decodes these to initiate decay.

The paper investigates the roles of Microprocessor and its cofactors ERH and SAFB1/2 in miRNA cluster assistance, revealing their distinct functional contributions to the process.

The paper identifies ERH and associated factors as post-transcriptional regulators of JAK2 mRNA maturation, essential for IFNγ signaling and innate immunity.

The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

GREEN-DB annotates and prioritizes non-coding regulatory variants from whole-genome sequencing data by integrating regulatory annotations, constraint metrics, and variant impact scores.

Nanopanel2 calls phased low-frequency variants in Nanopore panel sequencing data with high accuracy and low false positives.

VARAN-GIE is a tool for editing, annotating, and merging genomic interval sets, with support for data sharing and multiple formats.

Deep SNP uses a deep neural network with attention-based localization to detect genomic breakpoints in SNP array data, outperforming existing methods.